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RECEXiT

fteceipt is hereby acknowledged of Treasurer's Cheek
Hft.-g Q8ai8 , date d Au gust 12a gofiL-dnaon the

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in' the' amount of

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CONSULTANT

Pharmacology and toxicology

11 July 1964

For services rendered, June 1964

S 500. 00

$ cOiftii^ that servic'e? nr n a^ trials have been
Satisfactorily received tin pxponditui-eD
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TOTALS

31 March 1984

PROJECT CRYPTO

MK ULTRA 148

INVESTIGATOR : Dll

RENEWAL DATE

October 1964

1. This project provides^or the utilization of the
l>rofessional services of Dr.^^PHg| Since the initiation
of this project he has proved to be a reliable source of
information on the pharmacological and physiological infor-
mation^ji^^as^al chemical compounds of current interest in

(^-tht^HBHHHBprogram. The information provided has been
utiHSHPra^alntaining and advancing our k'nowledgeability
of unpublished data and information which permits us a
better basic understanding of the sites .of action of mat-
erials significant in influencing animal and human behavior
and guides us in selection of material and experimental
techniques.

2. He has reported on detailed experiments he was us-
ing to demonstrate that high and low spinal sections block-
ed the action of a dimethyl heptyl substituted tetrahydro-
cannabinol on the polysynaptic flexion reflex whereas the
mid brain section did not. The site of action is indicated
in the lower brain stem.

3. The consistant depressant action on these reflexes
is probably due to a summation of possible depressant act-
ions locally on the reflex system and at points in the
motor facilitory systems. It is hoped that work in this
area will eventually identify the mechanism responsible
for the ataxia produced by high doses of the active prin-
ciple of marihuana.

4. The long latent period experienced in the use of
C-9 may be attributed to the mineral or vegetable oil veh-
icle which is used frequently in oral dosage forms.

5. Attention has been called to the diethylamide of
2-methoxy-4-allyl phenoxy acetic acid which possesses a
narcotic and powerful analeptic respiratory action. It

-

causes stronger respiratory stimulation than that obtained
with most analeptics. ^ <2

S'm, This

trice it des-
Imicals and psy-
chemicals are of
a class which in-
Pentobarbital

6. A

was given to l^flHHaj^Lor review and
port is of coasiaeraole interest (tp
cribes interactions between pesticidaT chi
chotherapeutic compounds. The . pesticidal
the acetylcholinesterase inhibitor class,
eludes our CW organs phosphate materials,
and 1-Naphtbyl N- methyl carbamate ("Sevin") (a reversible
anticholinesterase material) gave directly additive respon-
ses. Chlorpromazine greatly augmented the response to
"Sevin". This was not related to changes in the brain
cholinesterase activity. Pilocarpine which does not block
cholinesterase increased and prolonged the anticholines-
terase .action of Sevin. This pattern offers interesting
possibilitit
interest tdf
Gr

7. Dr

and the state — — — ~ . .

gering epileptiform seizures in mammals. He will maintain
his contacts in the various domestic and overseas labor-
atories with a special within security on those

phenomena of interest PO-

8. Dr JHgBHp'ill continue to provide professional
services, r^relFHta set up protocols for critical pre-
clinical animal testing, will seek out sources of inform-

ad provide data available on direct request of

whenever data or information is [ xevfiaied to him
~ w‘tm > n , , l)e believes will be of Interest to

tei’action among materials of more direct

[is summarizing the latest information
tie art in setting the stage for and trig-

•ece request
isLxevgiyed

TOTALS

TOTALS

For services rendered, January 1964

I certify that services >n

satisfactorily received and the expenditures -

Consultant ,

Pharmacology and Toxicology

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nn i. ? :

24 October 1963

MBMOR/ifhlWs rOU

SUBJECT

MhltU/f ilA , Subproject Ko.

148

Under the surthoyi t>y granted An the signor anduiit tinted IS April lybo,

* ' • : ^ . ' -

froia the DC I to the DO/A, sad the extension ojf this authority in fcub-

ocquoat ueaorsufbi, Subprojectj.4.8 hr a been approved, and ^5,0p0_.m„.,.

of the over-all Project MXULTSA fund^ have been obligated to cover the

subproject :

and should be charged to coot center .4120-1390-3902

i

sMKUuRA

DRAFT

24 October 1963

MEMORANDUM FOR : TOE RECORD

SUBJECT

: MKULTRA, Subproject 148

1. The purpose of this subproject is to provide a mechanism

to utilize the professional services of Dr .

2. The services fall into the following categories, special
consultations, lectures, briefings, participation- in planning
sessions, participation in and reporting on special meetings and
conferences and provision of special information reflecting pro-
gress of research and development programs in laboratories known

to be conducting work of Interest toTjJ^Bi

3. Dr<fltt@S&ill, utilizing his posit ion as chairman of

the Department of Pharmacology]

conlmt ant ships with drug companies l"

and his direct entre into many U. S. and foreign academic labor-
atories, obtain and provide the very latest inf ormation and
findings in the field of pharmacology >fiich may he of interest

and value to the;

jrogram.

4. As a recognize^ authority in the^fieids of toxicology
and pharmacology, Dr. <|j j p|iiis personally acqu ainted with leaders
in the institutional and semi-industrial research and development

2

r '

>V»;\ULTRAi !

/#

// V y

laboratories and professional societies and can provide invalu-
able assistance and information unavailable thru normal channels.

5. The estimated cost of this program for one year is
$5,000.00. Charges should be made against Allotment Number
4125-1390-3902.

6. Payments to Dr,.

pvill be on a reimbursable basis
for professional services rendered.

Distribution:

Original only

24 October 1963

Category-

BEHAVIORAL ACTIVITIES SUPPORT

Advanced Research I _( Vic* y

Project Title — „ — N, A.

Item Classification—

Project Crypto-

Branch Project No-

Contractor.

MKULTRA

Crypto Classification Unc Unified

Contract No,.

■MKULTRA 148 Vasic jio-

Type of Contract

MKULTRA Date Initiated 1 . KovorahorjCiG3

, 000.00 FY 64 Com pletion Pate-

.October 31, 1964

Purno<;e- To provide mechanisms for professional services, physiological.
Purpose. ‘° la P^ cologlcal and-tcxlcotoglcal information on new Materials
and drugs currently in the research and development stage in
' certaiir institutional and pharmaceutical laboratories. This
activity will support TSD/BB activities concerned with in-.,
fluencing animal and hitman behavior.

Status: Being initiated.

Requirement: Internally generated in TS D 1 B f *°

several DD/P elements ircludi for support

requiree^H^ be“ in''tlie posit ion -tffTftailffaiir immediate re-
sponse capability. ~ ■

TOTALS

TOTALS

MEMORANDUM .FOR l

C/TSO/FASS

SUBJECT

MKULTRA,

Subproject Ko.

Under the authority granted in the rionorruidum oaten lo April lw«.> .
from the DCI to the DD/A, and the ©stony ion of this authority in sub-
sequent ECEOS'^da, Subproject J. 4 ^ _ baa been approved, and .,$5 f 000..0Q.,_.™

of the over-all Project MIIDI-TEA funds 'have • been obligated to cover ^ th©
subproject's expenses and should be charged to cost centor _4i2 5«,ia90-3902

Concur :

'AsSITl 3'iircf^‘“ 7 iSS~xor __ jp.SE „

Concur :

APPROVED FOR OBLIGATION
OF FbdPSi

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